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Miniature Ambient Ionization Mass Spectrometry System for Analysis of Microorganisms

Summary

Purdue University researchers have developed a novel method to analyze a sample containing one or more microorganisms. The method involves applying the sample to a porous material, adding a solvent, injecting a high voltage to generate ions, and then expelling the ions from the porous material in order to analyze them with a mass or mini mass spectrometer. With this method, the sample does not need culturing or prepping prior to analysis; it can be done with a solid, liquid, or gas. This technology provides a way to identify the microorganism down to its subspecies, substrain, and/or isolate level.

Technology Benefits

Biological samples can be stored in precut filter papers for monthsFilter paper minimizes matrix effects and enhances the MS signal of chemicals in complex samplesPaper can be pretreated to contain internal standards that are released at certain points in quantitative analysis

Technology Application

Chemical AnalysisBiotechnology

Detailed Technology Description

R. Graham CooksPurdue ChemistryAston Labs

Countries

United States

Application No.

8,710,437

Country/Region

USA

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