Miniature Ambient Ionization Mass Spectrometry System for Analysis of Microorganisms
Purdue University researchers have developed a novel method to analyze a sample containing one or more microorganisms. The method involves applying the sample to a porous material, adding a solvent, injecting a high voltage to generate ions, and then expelling the ions from the porous material in order to analyze them with a mass or mini mass spectrometer. With this method, the sample does not need culturing or prepping prior to analysis; it can be done with a solid, liquid, or gas. This technology provides a way to identify the microorganism down to its subspecies, substrain, and/or isolate level.
Biological samples can be stored in precut filter papers for monthsFilter paper minimizes matrix effects and enhances the MS signal of chemicals in complex samplesPaper can be pretreated to contain internal standards that are released at certain points in quantitative analysis
Chemical AnalysisBiotechnology
R. Graham CooksPurdue ChemistryAston Labs
United States
8,710,437
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