Sensitive Folate Receptor Detection by Immunomagnetic Diffractometry
- Summary
- Researchers at Purdue University have developed an integrated approach for the rapid detection of the folate receptor (FR) using in situ assembled optical diffraction gratings in combination with immunomagnetic capture. With this approach, a detection sensitivity of 700 fM (20 pg/ml) was achieved without any fluorescent or radiolabels or any secondary signal amplification. This approach can be applied to other targets and has the potential to be a broadly applicable, highly sensitive analysis technique.
- Technology Benefits
- Allows early detection of cancerSensitive to femtomolar concentrations Simpler assay with lower detection limit compared to current standard
- Technology Application
- Cancer DetectionMedical/Healthcare
- Detailed Technology Description
- Cagri SavranSavran Research GroupPurdue Mechanical Engineering
- Countries
- United States
- Application No.
- None
- *Abstract
-
- *Background
- Despite the diversity of available malignant disease detection platforms, important challenges still remain in minimizing sensor size, reducing detection time, eliminating target-labeling requirements, minimizing signal amplification steps, and developing simple and inexpensive fabrication protocols.
- *IP Issue Date
- None
- *IP Type
- Other Patent
- *Stage of Development
- Process Validation in Lab
- *Web Links
- Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipCagri SavranSavran Research GroupPurdue Mechanical Engineering
- Country/Region
- USA
For more information, please click Here
