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Sensitive Folate Receptor Detection by Immunomagnetic Diffractometry

總結: Researchers at Purdue University have developed an integrated approach for the rapid detection of the folate receptor (FR) using in situ assembled optical diffraction gratings in combination with immunomagnetic capture. With this approach, a detection sensitivity of 700 fM (20 pg/ml) was achieved without any fluorescent or radiolabels or any secondary signal amplification. This approach can be applied to other targets and has the potential to be a broadly applicable, highly sensitive analysis technique.

技術優勢: Allows early detection of cancerSensitive to femtomolar concentrations Simpler assay with lower detection limit compared to current standard

*Background: Despite the diversity of available malignant disease detection platforms, important challenges still remain in minimizing sensor size, reducing detection time, eliminating target-labeling requirements, minimizing signal amplification steps, and developing simple and inexpensive fabrication protocols.

*Web Links: Purdue Office of Technology CommercializationPurdueInnovation and EntrepreneurshipCagri SavranSavran Research GroupPurdue Mechanical Engineering

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