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Biomarkers for the Diagnosis of ALS

Detailed Technology Description: None

*Abstract: BackgroundAmyotrophic lateral sclerosis (ALS) is a chronic, progressive neurodegenerative disease of motor neurons in the cerebrum, brain stem and spinal cord with concurrent muscle weakness, wasting, and spasticity. ALS is the most common adult-onset motor neuron disease, with an incidence between 1.5 and 2 individuals per 100,000 per year. There is currently no rapid diagnostic test for ALS, with diagnosis based on clinical parameters.TechnologyInvestigators have developed methods for determining the onset of ALS. A sample of cerebral spinal fluid (CSF) is analyzed for the presence of one or more biomarkers indicative of ALS. The biomarkers are one or more of the following: C-reactive protein (CRP), cystatin c, plasminogen, complement C3, CysGly-transthyretin, and phosphorylated neurofilament heavy chain (pNFH). Application* Determination of the onset of ALS* Monitor the progression of ALS* Monitor the progression of a treatment for ALSAdvantages* No rapid diagnostic test for ALS currently exists

*Principal Investigator: Name: Robert Bowser
Department: Division of Neurology

Country/Region: USA

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