Extracellular NAD is a Potent Anti-Inflammatory Agent
- Detailed Technology Description
- None
- *Abstract
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A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or ulcerative colitis) or systemic causes of inflammation (e.g., endotoxemia, sepsis, hemorrhagic shock/resuscitation or pancreatitis) is disclosed. In the method of the invention, an affected patient is administered a therapeutically effective amount of a composition including an NAD-related compound, in a form that is accessible to a receptor molecule, conveyed in a pharmaceutically acceptable carrier vehicle. Also disclosed are ex vivo and in vivo assay methods to test candidate compounds for activity, kits for carrying out the therapeutic methods or the assay methods of the invention and articles of manufacture that include compositions for use in the methods of the invention and instructions for the use thereof. Non Provisional and PCT Patent Applications Filed
- *Principal Investigator
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Name: Russell Delude, Assistant Professor
Department: Med-Critical Care Medicine
Name: Mitchell Fink, Professor
Department: Med-Critical Care Medicine
Name: Xianonan Han, Postdoctoral Fellow
Department: Critical Care Medicine
- Country/Region
- USA
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