Media.Player

Extracellular NAD is a Potent Anti-Inflammatory Agent

詳細技術說明

None

*Abstract

A method of prophylaxis or treatment of inflammatory conditions, including, but not limited to, intestinal epithelial inflammation due to intestine-specific conditions (e.g., Crohn's disease or ulcerative colitis) or systemic causes of inflammation (e.g., endotoxemia, sepsis, hemorrhagic shock/resuscitation or pancreatitis) is disclosed. In the method of the invention, an affected patient is administered a therapeutically effective amount of a composition including an NAD-related compound, in a form that is accessible to a receptor molecule, conveyed in a pharmaceutically acceptable carrier vehicle. Also disclosed are ex vivo and in vivo assay methods to test candidate compounds for activity, kits for carrying out the therapeutic methods or the assay methods of the invention and articles of manufacture that include compositions for use in the methods of the invention and instructions for the use thereof. Non Provisional and PCT Patent Applications Filed

*Principal Investigation

Name: Russell Delude, Assistant Professor

Department: Med-Critical Care Medicine

Name: Mitchell Fink, Professor

Department: Med-Critical Care Medicine

Name: Xianonan Han, Postdoctoral Fellow

Department: Critical Care Medicine

國家/地區

美國