Methods For The Identification Of Inhibitors Of Threonine Synthase As Antibiotics
The Present Inventors Have Discovered That Threonine Synthase Is Essential For Fungal Pathogenicity. Specifically, The Inhibition Of Threonine Synthase Gene Expression In Fungi Results In No Signs Of Successful Infection Or Lesions. Thus, Threonine Synthase Can Be Used As A Target For The Identification Of Antibiotics, Preferably Antifungals. Accordingly, The Present Invention Provides Methods For The Identification Of Compounds That Inhibit Threonine Synthase Expression Or Activity. The Methods Of The Invention Are Useful For The Identification Of Antibiotics, Preferably Antifungals.
Inventor: KAELIN, William, G. | IVAN, Mircea
Priority Number: WO2002074980A2
IPC Current: C12N001509 | A61K003800 | A61K003802 | A61K003817 | A61K003844 | A61K004800 | A61P000900 | A61P001702 | C07K001447 | C07K001618 | C12N000115 | C12N000119 | C12N000121 | C12N000510 | C12Q000126 | G01N0033573
Assignee Applicant: Dana-Farber Cancer Institute Inc.
Title: MUTEINS OF HYPOXIA INDUCIBLE FACTOR ALPHA AND METHODS OF USE THEREOF | MUTEINES DU FACTEUR DE TRANSCRIPTION ALPHA INDUCTIBLE EN HYPOXIE
Usefulness: MUTEINS OF HYPOXIA INDUCIBLE FACTOR ALPHA AND METHODS OF USE THEREOF | MUTEINES DU FACTEUR DE TRANSCRIPTION ALPHA INDUCTIBLE EN HYPOXIE
Summary: The methods and compositions of the present invention are useful for reducing, preventing or treating hypoxia or ischemia-related tissue damage, and/or increasing angiogenesis and vascularization (claimed).
Novelty: New HIF-alpha mutein polypeptide and encoding nucleic acid, useful for reducing, preventing or treating hypoxia or ischemia-related tissue damage, and/or increasing angiogenesis and vascularization
Disease Diagnostic/Treatment
Other Disease
Hong Kong
