Heart failure is a major cause of death and disability in both developed and developing countries. Major clinical conditions associated with heart failure include: 1) End-stage chronic heart failure (including ischemic and non-ischemic cardiomyopathy), 2) Acute decompensated heart failure, and 3) Ac.....
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Highlights:p53, the most important tumour suppressor protein in the cell, is a homotetrameric protein that has a pivotal role in the cellular anti cancer defense mechanism.p53 is active as a tetramer: the tetramer binds DNA much tighter than the monomer / dimer and is retained in the nucleus while t.....
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