Highlights:p53, the most important tumour suppressor protein in the cell, is a homotetrameric protein that has a pivotal role in the cellular anti cancer defense mechanism.p53 is active as a tetramer: the tetramer binds DNA much tighter than the monomer / dimer and is retained in the nucleus while t.....
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A subchondral defect is usually characterized by a structural breakdown of the articular cartilage and the bone underneath due to trauma or disease, leading to chronic disabilities. Treating such defects is an important medical target since in the adult patient, damaged cartilage cannot spontaneousl.....
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A universal computational framework for identifying molecular pathways underlying cancer viability and resistance. Our approach is applied to mining large collections of cancer patients’ data and identifying classes of genetic interactions termed synthetic lethality (SL). Synthetic lethality - The d.....
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Intraocular pressure (IOP), an important part of any eye exam, is measured with a special instrument called a tonometer. The most widely employed devices are the Goldmann and the air-puff tonometers. In both, the intraocular pressure is inferred from the force required to flatten (applanate) a const.....
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