Gene Editing: An Improved Methodology For Homology Directed Repair In Cells
This new invention has been found to increase the HDR efficiency by 2- to 15-fold
The invention has wide applications including use in treatment of human genetic diseases as well as performing genetic engineering on cells or organisms with the goal of producing better pharmaceuticals.
Researchers at UC San Diego have developed a method to increase the efficiency of homology directed repair (HDR). This method uses CRISPR-Cas9 technology to generate the DNA double-strand breaks, and then employs a novel approach for HDR. In some instances, this method also decreases the amount of cell death that occurs during the HDR process.
State Of Development A working research model. Intellectual Property Info This technology is patent pending and available for licensing and/or research sponsorship. Tech ID/UC Case 29620/2018-298-0 Related Cases 2018-298-0
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