In Utero Prevention Of Congenital Heart Disease By Metabolic Intervention
This chemical is already FDA-approved for alternate indications No current strategies to decrease risk of congenital heart disease More effective than controlling maternal blood glucose levels
Prevention of congenital heart disease
Professor Nakano and coworkers have discovered an in utero treatment to prevent CHD. A chemical screen revealed that high maternal glucose levels interfered with development of heart muscle cellsviaa key regulatory pathway. By inhibiting this pathway using the FDA-approved small molecule, CHD could be prevented in mouse models. This chemical has been shown to cross the placental barrier and is non-toxic and efficacious at the dose used in this method.
State Of Development Preliminary experiments have been carried out in mice. This chemical has been shown to prevent congenital heart disease without detectable side effect. Background Congenital heart disease (CHD) is a heterogeneous group of structural anomalies in the heart that is present in 0.8% of newborn infants worldwide. Although the advance in pre-natal diagnosis allows us to detect CHD and assess the risk early during pregnancy, corrective surgery is currently the only effective option and there is no way to prevent the progression of CHD. Therefore, the financial, emotional and social burden of the families with a baby with CHD is huge. While the cause of CHD may vary, maternal hyperglycemia is associated with a 5-fold increase in CHD risk. Careful monitoring and control of the mother’s blood glucose level has not been proven to be effective in preventing CHD. With rapidly increasing prevalence of diabetic pregnancy and high incidence of CHD, how to treat CHD will be an urgent issue in medical practice and medical economy in the next few decades. Related Materials Tech ID/UC Case 29355/2017-725-0 Related Cases 2017-725-0
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