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In Utero Prevention Of Congenital Heart Disease By Metabolic Intervention

技术优势

This chemical is already FDA-approved for alternate indications No current strategies to decrease risk of congenital heart disease More effective than controlling maternal blood glucose levels

技术应用

Prevention of congenital heart disease

详细技术说明

Professor Nakano and coworkers have discovered an in utero treatment to prevent CHD. A chemical screen revealed that high maternal glucose levels interfered with development of heart muscle cellsviaa key regulatory pathway. By inhibiting this pathway using the FDA-approved small molecule, CHD could be prevented in mouse models. This chemical has been shown to cross the placental barrier and is non-toxic and efficacious at the dose used in this method.

*Abstract

UCLA researchers in the Department of Molecular Cell and Developmental Biology have discovered a method of preventing congenital heart disease through in utero treatment.

*Principal Investigation

Name: Atsushi Nakano

Department:

Name: Haruko Nakano

Department:

其他

State Of Development

Preliminary experiments have been carried out in mice. This chemical has been shown to prevent congenital heart disease without detectable side effect.

Background

Congenital heart disease (CHD) is a heterogeneous group of structural anomalies in the heart that is present in 0.8% of newborn infants worldwide. Although the advance in pre-natal diagnosis allows us to detect CHD and assess the risk early during pregnancy, corrective surgery is currently the only effective option and there is no way to prevent the progression of CHD. Therefore, the financial, emotional and social burden of the families with a baby with CHD is huge. While the cause of CHD may vary, maternal hyperglycemia is associated with a 5-fold increase in CHD risk. Careful monitoring and control of the mother’s blood glucose level has not been proven to be effective in preventing CHD. With rapidly increasing prevalence of diabetic pregnancy and high incidence of CHD, how to treat CHD will be an urgent issue in medical practice and medical economy in the next few decades.

Related Materials

Nakano, H.; Minami, I.; Braas, D.; Pappoe, H.; Wu, X.; Sagadevan, A.; Vergnes, L.; Fu, K.; Morselli, M.; Dunham, C.; Ding, X.; Stieg, A. Z.; Gimzewski, J. K.; Pellegrini, M.; Clark, P. M.; Reue, K.; Lusis, A. J.; Ribalet, B.; Kurdistani, S. K.; Christofk, H.; Nakatsuji, N.; Nakano, A. Glucose inhibits cardiac muscle maturation through nucleotide biosynthesis. eLife. 2017.

Tech ID/UC Case

29355/2017-725-0

Related Cases

2017-725-0

国家/地区

美国