Hybrid ceramic/hydrogel scaffolds for cartilage-bone interface regeneration
For patients with osteoarthritis, damaged cartilage has a limited potential for self-repair, and as a result, surgery is often necessary. Osteochondral grafts have emerged as an attractive alternative or supplement to surgery for cartilage repair. While these grafts are capable of regenerating both bone and cartilage-like tissues, the ability to form a stable osteochondral interface between these two tissues remains a challenge. This technology combines a biomimetic hydrogel with a ceramic scaffold for regeneration of calcified cartilage and bone, as well as stable integration at the bone-cartilage interface. This technology may be developed to serve as an implantable osteochondral graft for the treatment of osteoarthritis and other diseases or injuries of the cartilage.
Chondrocyte response can be modulated by varying both ceramic and hydrogel componentsGrafts form a stable cartilage-bone interfaceCan be expanded to other types of tissue generationPatent Information:Patent Pending (US20160058912)Patent Pending (WO/2014/169236)Tech Ventures Reference: IR CU14091
Regeneration of calcified cartilage and underlying boneStable integration between cartilage and bone at the osteochondral interfaceGeneration of other tissues from stem cells
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