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Hybrid ceramic/hydrogel scaffolds for cartilage-bone interface regeneration

Summary

For patients with osteoarthritis, damaged cartilage has a limited potential for self-repair, and as a result, surgery is often necessary. Osteochondral grafts have emerged as an attractive alternative or supplement to surgery for cartilage repair. While these grafts are capable of regenerating both bone and cartilage-like tissues, the ability to form a stable osteochondral interface between these two tissues remains a challenge. This technology combines a biomimetic hydrogel with a ceramic scaffold for regeneration of calcified cartilage and bone, as well as stable integration at the bone-cartilage interface. This technology may be developed to serve as an implantable osteochondral graft for the treatment of osteoarthritis and other diseases or injuries of the cartilage.

Technology Benefits

Chondrocyte response can be modulated by varying both ceramic and hydrogel componentsGrafts form a stable cartilage-bone interfaceCan be expanded to other types of tissue generationPatent Information:Patent Pending (US20160058912)Patent Pending (WO/2014/169236)Tech Ventures Reference: IR CU14091

Technology Application

Regeneration of calcified cartilage and underlying boneStable integration between cartilage and bone at the osteochondral interfaceGeneration of other tissues from stem cells

Detailed Technology Description

None

*Abstract

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*Inquiry

Satish RaoColumbia Technology VenturesTel: (212) 854-8444Email: TechTransfer@columbia.edu

*IR

cu14091

*Principal Investigator

*Publications

Wan LQ, Jiang J, Arnold DE, Guo XE, Lu HH, Mow VC. “Calcium Concentration Effects on the Mechanical and Biochemical Properties of Chondrocyte-Alginate Constructs.” Cell Mol Bioeng. 2008 Mar 1;1(1):93-102.Jiang J, Tang A, Ateshian GA, Guo XE, Hung CT, Lu HH. “Bioactive stratified polymer ceramic-hydrogel scaffold for integrative osteochondral repair.” Ann Biomed Eng. 2010 Jun;38(6):2183-96.Wan LQ, Jiang J, Miller DE, Guo XE, Mow VC, Lu HH. “Matrix deposition modulates the viscoelastic shear properties of hydrogel-based cartilage grafts.” Tissue Eng Part A. 2011 Apr;17(7-8):1111-22.Khanarian NT, Jiang J, Wan LQ, Mow VC, Lu HH. “A hydrogel-mineral composite scaffold for osteochondral interface tissue engineering.” Tissue Eng Part A. 2012 Mar;18(5-6):533-45.Khanarian NT, Haney NM, Burga RA, Lu HH. “A functional agarose-hydroxyapatite scaffold for osteochondral interface regeneration.” Biomaterials. 2012 Jul;33(21):5247-58.

Country/Region

USA