Second harmonic generation for measuring the relative orientation in a pair of DNA-binding molecules
Kenneth Eisenthal, Ph.D.
Measures drug-induced DNA unwinding.Acquires data in solution more closely mimicking the DNA environment in vivo.Improves research and development of new DNA-binding drug candidates.Patent information:Patent Pending (US/2012/0202296)Tech Ventures Reference: IR CU13153
Screen the effects of DNA-binding compounds on DNA unwinding.Probe basic structural features of biochemical complexes for the study of structural biology.Provide information on other potential structural changes induced by drug binding distinct from DNA unwinding, such as kinking or supercoiling.Use as a general DNA binding assay if SHG intensity reproducibly changes when a compound binds to DNA.
Kenneth Eisenthal, Ph.D.
美國
