Recovery of Function In Chronic Spinal Cord Injury
Purdue University researchers have developed chemical analogues of 4-AP with superior pharmacological properties compared to the parent compound. Special analogues and cocrystals of the compound 4-AP were synthesized and their biological properties were tested. These compounds and all related derivatives and prodrugs dissolve readily at stomach pH facilitating the distribution of the parent compound and the analogues through the body subsequent to oral intake. These drugs (under stomach pH) have been shown to improve nerve impulse conduction through injured spinal cords in in vitro experimental models.
More effective than 4-APLong-term stability Slow dissolutionFacilitates ease of clinical administration
Medical/HealthcarePharmaceuticals
Richard BorgensCenter for Paralysis ResearchPurdue Biomedical Engineering
United States
8,097,638
美國