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Recovery of Function In Chronic Spinal Cord Injury

Summary

Purdue University researchers have developed chemical analogues of 4-AP with superior pharmacological properties compared to the parent compound. Special analogues and cocrystals of the compound 4-AP were synthesized and their biological properties were tested. These compounds and all related derivatives and prodrugs dissolve readily at stomach pH facilitating the distribution of the parent compound and the analogues through the body subsequent to oral intake. These drugs (under stomach pH) have been shown to improve nerve impulse conduction through injured spinal cords in in vitro experimental models.

Technology Benefits

More effective than 4-APLong-term stability Slow dissolutionFacilitates ease of clinical administration

Technology Application

Medical/HealthcarePharmaceuticals

Detailed Technology Description

Richard BorgensCenter for Paralysis ResearchPurdue Biomedical Engineering

Countries

United States

Application No.

8,097,638

Country/Region

USA

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