A-31 Novel Drug Candidate for Neurodegenerative Diseases
ΓùÅ This analog 1 can be synthesized from inexpensive sodium cholate in 16 steps for an 11% total yieldΓùÅ This analog showed NGF-enhancing activity against neuronal cellsΓùÅ This analog showed memory recovery effect on aged and senescence-accelerated mice
This novel compound can be applied to a new drug for neurodegenerative diseases.
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Patent Number: US7605265B2
Application Number: US2007625603A
Inventor: Ip, Nancy Y | Ip, Fanny Chui Fun | Hu, Yueqing | Han, Yifan | Chung, Sookja Kim
Priority Date: 22 Jan 2007
Priority Number: US7605265B2
Application Date: 22 Jan 2007
Publication Date: 20 Oct 2009
IPC Current: C07D021912 | C07D021722
US Class: 546106 | 546141
Assignee Applicant: Biotechnology Research Corporation Ltd.
Title: Heterodimers and methods of using them
Usefulness: Heterodimers and methods of using them
Summary: For inhibiting cholinesterase e.g. acetylcholinesterase or butyrylcholinesterase and N-methyl-D-aspartate receptor; in the preparation of pharmaceutical composition for treating a disease or disorder of the nervous system in an animal (preferably human) i.e. neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, epileptic fit, dementia, epilepsy, brain trauma, cognitive disorders (claimed), chronic pain, central nervous system disorders and ischemia.
Novelty: New heterodimers of tetrahydroacridines and tetrahydroquinolinones for treating neurodegenerative disease e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, dementia, epilepsy, brain trauma and cognitive disorders
化工/材料
化工/材料應用
美國
