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A-31 Novel Drug Candidate for Neurodegenerative Diseases

技术优势

ΓùÅ This analog 1 can be synthesized from inexpensive sodium cholate in 16 steps for an 11% total yieldΓùÅ This analog showed NGF-enhancing activity against neuronal cellsΓùÅ This analog showed memory recovery effect on aged and senescence-accelerated mice

技术应用

This novel compound can be applied to a new drug for neurodegenerative diseases.

详细技术说明

None

*Abstract

Researchers at Nagoya University and Meijo University have synthesized a novel neurotrophic factor (NGF)-enhancing compound, which shows memory recovery effects on aged mice and senescence-accelerated mice (SAM). This compound is designed based on a steroid glycoside discovered from Okinawan Crown-of-Thorns Starfish. Researchers have found that the starfish-derived compound has NGF-enhancing (in vitro) and memory recovery effects (in vivo) and can pass through the blood-brain barrier. However, the quantity of starfish derived compound is very limited in nature. To solve this problem, researchers synthesized a compound (analog 1), which shows medicinal effects comparable to those of the natural steroid glycoside.

附加资料

Patent Number: US7605265B2
Application Number: US2007625603A
Inventor: Ip, Nancy Y | Ip, Fanny Chui Fun | Hu, Yueqing | Han, Yifan | Chung, Sookja Kim
Priority Date: 22 Jan 2007
Priority Number: US7605265B2
Application Date: 22 Jan 2007
Publication Date: 20 Oct 2009
IPC Current: C07D021912 | C07D021722
US Class: 546106 | 546141
Assignee Applicant: Biotechnology Research Corporation Ltd.
Title: Heterodimers and methods of using them
Usefulness: Heterodimers and methods of using them
Summary: For inhibiting cholinesterase e.g. acetylcholinesterase or butyrylcholinesterase and N-methyl-D-aspartate receptor; in the preparation of pharmaceutical composition for treating a disease or disorder of the nervous system in an animal (preferably human) i.e. neurodegenerative disease such as Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, epileptic fit, dementia, epilepsy, brain trauma, cognitive disorders (claimed), chronic pain, central nervous system disorders and ischemia.
Novelty: New heterodimers of tetrahydroacridines and tetrahydroquinolinones for treating neurodegenerative disease e.g. Alzheimer's disease, Parkinson's disease, Huntington's disease, stroke, dementia, epilepsy, brain trauma and cognitive disorders

主要类别

化工/材料

细分类别

化工/材料应用

国家/地区

美国