ALXAN
8-Etinylxanthines: potent dual-target-directed adenosine receptor antagonists with a beneficial neuroprotective function in Parkinson’s and Alzheimer’s disease.
New potent dual- and triple-target drugs for the treatment of PD and AD
Multi-target drug with improved compliance, less side effects, reduced toxicity
Significant advantages over combination therapy: more predictable pharmacology, reduced drug-drug interactions, less complex pharmacokinetics
these observations position tricyclic xanthine derivatives as ideal candidates for the treatment of neurodegenerative diseases such as PD and AD, but might also be suitable for the treatment of depression, addiction and restless legs syndrome.
This invention provides newly designed tricyclic xanthine derivatives which allow overcoming this problem. A variety of 69 derivatives were prepared and evaluated in radioligand binding studies at adenosine receptors and for their ability to inhibit monoamine oxidases. Potent dual-target-directed A1/A2A adenosine receptor antagonists were identified. Several compounds even showed triple-target inhibition.
Licensing
28/06/2011 00:00:00
EP20070856895 20071219
- international:
A61K31/495; A61P25/00; C07D473/04; C07D473/06
- cooperative:
C07D473/04; C07D473/06
Patent application
1613
德国
