Gold Catalyzed Hydroamination of Alkynes and Allenes
Hydroamination of alkynes and allenes Production of pharmaceuticals/bioactive molecules
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8580990
Background Nitrogen-carbon bonds are found in a variety of compounds, ranging from pharmaceuticals to chemical feedstocks. Specifically, the formation of C-N bonds is done via hydroamination, which adds the N-H bond of an amine group to a carbon-carbon bond via a catalyst, which is a compound that increases the rate of a chemical reaction without being consumed. This process is especially important in the synthesis of biologically active compounds. Related Materials Tech ID/UC Case 29208/2008-598-0 Related Cases 2008-598-0
Ammonia is among the cheapest, most readily available bulk chemicals, which has led to a widespread interest in developing techniques that can combine ammonia with organic molecules. Of particular interest is combining ammonia with multiple-bonded carbon atoms (such as those in alkynes and allenes).
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