Surface Treatment for Blood-Contacting Materials
ApplicationNew technologydeveloped by UGA researchers combines the clot-preventing capabilities ofliquid infused porous materials with the antibacterial effects of Nitrous Oxide.This combination can have great impact in many blood-contacting devices,serving as the base material (for applications such as tubing, catheters,stents, vascular grafts, extracorporeal circulation, urinary catheters, etc.)or coatings of other implantable devices. Liquid infused porous surfaces showhuge potential due to their ability to greatly reduce bacterial adhesion andclotting in blood-contacting devices. Another method to improve thebiocompatibility of these blood-contacting materials is the deployment ofNitric Oxide (NO). NO is a small, naturally produced molecule which the bodyuses to decrease the activation of platelets as they flow in the blood streamand to kill unwanted bacteria. NO is also released from the sinuses as apreventative measure to reduce the risk of infection. Combining the use ofliquid infused materials with the natural antibacterial molecule, NO, creates asynergistic effect that produces the benefits of both methods, while negatingthe protein clotting effects of NO has individually. The infused liquid willprovide a thin barrier between the material and contacting fluids (such asblood), while actively reducing platelet adhesion and activation. The NO in theliquid will also kill any bacteria that have adhered to the surface.
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