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Method of Neuronal Stem Cell Production

技术优势

The current method provides an in vitro renewable source of neural stem cells.

技术应用

Possible commercial applications include cell-based therapies for treating a neurological disorder and culture media supplements. In addition to therapeutic uses, neural stem cells made in accordance with this method may also have applications in basic research, drug discovery and disease modeling.

详细技术说明

UC San Diego investigators have developed a method for obtaining neural stem cells from embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC). The method includes the steps of culturing ESC or iPSC in a medium comprising leukemia inhibitory factor (LIF), an inhibitor of glycogen synthase kinase 3 (GSK3) and an inhibitor of transforming growth factor-beta (TGF-β). Neural stem cells made in accordance with the method may be administered to a patient to treat a neurological disorder, for example Parkinson’s disease, or an eye disease such as macular degeneration or glaucoma. The invention also provides a culture media supplement comprising LIF, GSK3 and TGF-β

附加资料

Patent Number: CN101422865B
Application Number: CN200710164361A
Inventor: Zhaohui Lan | Zheng Jiang | Ruxu Du | Xueyan Tang
Priority Date: 30 Oct 2007
Priority Number: CN101422865B
Application Date: 30 Oct 2007
Publication Date: 29 Sep 2010
IPC Current: B23Q001100 | B23Q000300 | B23Q001104
Assignee Applicant: The Chinese University of Hong Kong
Title: Clamping device and method for processing workpiece | Method clamp device and processing said work piece
Usefulness: Clamping device and method for processing workpiece | Method clamp device and processing said work piece
Summary: Clamp device.
Novelty: Clamp device, has clamping component movably fixedly connected with fixing component, and elastic part axially extended to fixing component, and ends at connecting part that is radially extended and fixed on fixing component