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Method of Neuronal Stem Cell Production

技術優勢

The current method provides an in vitro renewable source of neural stem cells.

技術應用

Possible commercial applications include cell-based therapies for treating a neurological disorder and culture media supplements. In addition to therapeutic uses, neural stem cells made in accordance with this method may also have applications in basic research, drug discovery and disease modeling.

詳細技術說明

UC San Diego investigators have developed a method for obtaining neural stem cells from embryonic stem cells (ESC) or induced pluripotent stem cells (iPSC). The method includes the steps of culturing ESC or iPSC in a medium comprising leukemia inhibitory factor (LIF), an inhibitor of glycogen synthase kinase 3 (GSK3) and an inhibitor of transforming growth factor-beta (TGF-β). Neural stem cells made in accordance with the method may be administered to a patient to treat a neurological disorder, for example Parkinson’s disease, or an eye disease such as macular degeneration or glaucoma. The invention also provides a culture media supplement comprising LIF, GSK3 and TGF-β

*Abstract

Cell-based therapeutics and research and development in the area of neural injury and neurological disorders could benefit from a renewable source of neural stem cells. Human embryonic stem cells provide indefinitely self-renewing cells with differentiation potential, but are inferior to lineage-restricted cells as they are prone to causing teratomas and fail to repopulate host tissues in vivo. Significant challenges in isolation and long-term cultivation of tissue-specific stem cells has restricted broad use of neural stem cells. Accordingly, there is a need for a method for obtaining a renewable source of neural stem cells.

*IP Issue Date

Nov 11, 2014

*Principal Investigation

Name: Sheng Ding

Department:

Name: Kang Zhang

Department:

附加資料

Patent Number: CN101422865B
Application Number: CN200710164361A
Inventor: Zhaohui Lan | Zheng Jiang | Ruxu Du | Xueyan Tang
Priority Date: 30 Oct 2007
Priority Number: CN101422865B
Application Date: 30 Oct 2007
Publication Date: 29 Sep 2010
IPC Current: B23Q001100 | B23Q000300 | B23Q001104
Assignee Applicant: The Chinese University of Hong Kong
Title: Clamping device and method for processing workpiece | Method clamp device and processing said work piece
Usefulness: Clamping device and method for processing workpiece | Method clamp device and processing said work piece
Summary: Clamp device.
Novelty: Clamp device, has clamping component movably fixedly connected with fixing component, and elastic part axially extended to fixing component, and ends at connecting part that is radially extended and fixed on fixing component

主要類別

生物醫學

細分類別

生物工程

申請號碼

8883502

其他

State Of Development

Proof-of-principle production of primitive neural precursor cells from human embryonic stem cells.

Related Materials

Li et al, Proc Natl Acad Sci USA, 2011 May 17; 108(20):8299-304, “Rapid induction and long-term self-renewal of primitive neural precursors from human embryonic stem cells by small molecule inhibitors”.

Tech ID/UC Case

23519/2011-059-0

Related Cases

2011-059-0

國家/地區

美國