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Gene Editing: An Improved Methodology For Homology Directed Repair In Cells

Technology Benefits

This new invention has been found to increase the HDR efficiency by 2- to 15-fold

Technology Application

The invention has wide applications including use in treatment of human genetic diseases as well as performing genetic engineering on cells or organisms with the goal of producing better pharmaceuticals.

Detailed Technology Description

Researchers at UC San Diego have developed a method to increase the efficiency of homology directed repair (HDR). This method uses CRISPR-Cas9 technology to generate the DNA double-strand breaks, and then employs a novel approach for HDR. In some instances, this method also decreases the amount of cell death that occurs during the HDR process.

Others

State Of Development

A working research model.

Intellectual Property Info

This technology is patent pending and available for licensing and/or research sponsorship.

Tech ID/UC Case

29620/2018-298-0

Related Cases

2018-298-0

Country/Region

USA

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