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Inhibitors for Protein alpha-N-terminal Methyltransferases

Summary

Researchers at Purdue University have developed new potent inhibitors for the protein NTMT. The inhibitor exhibited high selectivity to NTMT1/2 over a panel of 41 methyltransferases. These chemical compounds are novel because they are amenable for cell-based studies. They may be further optimized for animal studies. This technology is more stable and cell-permeable than existing solutions. This technology could open the door for elucidate the pharmacological functions of protein NTMT1.

Technology Benefits

Amenable for cell based studiesDisplays selective inhibition for NTMT1May be used for animal studies

Technology Application

Cell based studiesAnimal studies

Detailed Technology Description

Rong HuangHuang Research Lab

Countries

United States

Application No.

None

Country/Region

USA

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