Graphene Nanomesh As A Glucose Sensor

High sensitivity, sensitivity, and fast response speed  The ambipolar field characteristic of graphene sensors enables the detection of both positively and negatively charged species  Free of “oxygen deficit” problem

Monitor blood glucose concentration in diabetes care  In vivo glucose sensing

Researchers at UCLA have developed a novel glucose sensing mechanism based on the doping effect of H2O2 to GNM. They have demonstrated the capability of GNM-based field effect transistor devices as an effective glucose sensor, and also solved the “oxygen deficit” problem since nanoscale GNM glucose sensor consumes little oxygen due to its small size. Meanwhile, the exceptionally high carrier mobility and large surface to volume ratio of graphene-based sensors provide these new glucose sensors with high sensitivity and fast response speed.

State Of Development

The proposed glucose sensing mechanism has been tested.

Background

A GNM consists of a single or few-layers of graphene with a high density periodic array of nanoholes punched in. This unique structure of GNM overcomes several limitations of graphene, leading to appreciable band gap and transconductance at room temperature as well as higher functional group density, making it a promising material for graphene-based chemical sensor and biosensor applications.

Currently, most glucose sensors are based on electrochemical reactions by using amperometric enzyme electrodes. These glucose sensors rely on the detection of hydrogen peroxide generated by glucose oxidase catalyzed redox reaction through amperometric electrodes, and they tend to have relatively low selectivity because the anodic current can be introduced by oxidation of other chemicals in the environment. They also suffer from “oxygen deficit,” as the performance of the sensor is subject to errors caused by fluctuation of oxygen tension if oxygen is not in non-rate limiting excess after consumption by the glucose oxidase catalyzed reaction. Another type of glucose sensor utilizes an electron mediator which shuttles electrons between the electrode and enzyme as a substitute of oxygen. However, the mediator is usually toxic and the sensor is not appropriate to work in vivo.

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• Chemical Vapor Deposition Growth of the Large Single Crystalline Domains of Monolayer and Bilayer
• Graphene Based Catalysts for Biomimetric Generation of Antithrombotic Species
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• Electrochemical Molecular Intercalation for Synthesis of Monolayer Atomic Crystal Molecular Superlattices

Tech ID/UC Case

29407/2011-419-0

Related Cases

2011-419-0

USA