Hexachlorophene for the Treatment of ALS and Related Disorders

Endogenous TDP-43 accumulation is decreasedOverexpressed TDP-43 accumulation is decreasedTreatment option for ALS

therapeutic agent for ALS

Accumulation of TDP-43 protein is a major causative agent for the pathogenesis of ALS and other neurodegenerative diseases. So far, there is no cure or treatment for diseases related to TDP-43.To identify drug candidates that are capable of targeting TDP-43, two different cell based TDP-43 models were used: cells expressing endogenous TDP-43 protein and cells overexpressing wild-type human TDP-43. Hexachlorophene showed a dramatic reduction in both endogenous as well as overexpressed TDP-43 levels. Hexachlorophene could therefore serve as a potential therapeutic agent for the treatment of ALS and other related disorders.

USA