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Highly Specific Paper-based Detection of Neonatal Sepsis

Summary

Researchers at Purdue University have developed bench-top molecular biology detection into a portable and easy-to-use paper test strip. Assay time is decreased (less than 1.5 hours) by adjusting LAMP reagent concentration, and its high selectivity decreases the amount of false positives. In addition, this detection strip is within the amplification reaction itself and does not require downstream steps to perform detection. The paper effectively prepares, amplifies, and detects bacterial nucleic acids, such as E. coli, from infected whole-blood samples for rapid sample-to-answer disease detection.

Technology Benefits

Decreased assay timeDecreased false positivesEffective amplificationPortable/easy to use

Technology Application

Rapid disease detectionDiagnose sepsis in neonatal infants

Detailed Technology Description

Jacqueline LinnesLinnes LabPurdue Biomedical Engineering

Countries

United States

Application No.

None

Country/Region

USA

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