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Accelerated Degradation of Pharmaceuticals and Related Chemical Processes

Summary

Researchers at Purdue University have developed a new forced degradation method. Using Leidenfrost droplets to accelerate forced degradation and nanospray mass spectrometry (MS) to characterize the reaction products, the reaction/analysis sequence provided results within minutes, i.e., five minutes, versus taking up to a week to complete. The FDA requires forced degradation for licensing, which causes a bottleneck in pharmaceutical production. An accelerated forced degradation method could help eliminate this bottleneck.

Technology Benefits

FasterMore efficientReliablePotential to speed up FDA licensing process

Technology Application

Pharmaceutical industryDrug development

Detailed Technology Description

R. Graham CooksPurdue ChemistryAston Labs

Countries

United States

Application No.

None

Country/Region

USA

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