A Dual-RNA Guided CasZ Gene Editing Technology

Adds additional versatility because of small size Variant PAM

Genome editing Genetic engineering Gene therapy Research tools (e.g., high-throughput screening of gene functions in cell lines and in vivo) Creation of transgenic animal models

None

Additional Technologies by these Inventors

• Compositions and Methods of Use for Variant Csy4 Endoribonucleases
• Methods and Compositions for Controlling Gene Expression by RNA Processing
• Structure-Guided Methods Of Cas9-Mediated Genome Engineering
• Methods and Compositions for Using Argonaute to Modify a Single-Stranded Target Nucleic Acid
• Efficient Site-Specific Integration Of New Genetic Information Into Human Cells
• Cas9 Variants With Altered DNA Cleaving Activity
• Split-Cas9 For Regulatable Genome Engineering
• Single-Stranded Nucleic Acid Detection And Imaging System Using Cas9
• Methods For High Signal-To-Noise Imaging Of Chromosomal Loci In Cells Using Fluorescent Cas9
• Identification Of Sites For Internal Insertions Into Cas9
• Cas13a/C2c2 - A Dual Function Programmable RNA Endoribonuclease
• Small Molecule Assisted Cell Penetrating Cas9 RNP Delivery
• THERMOSTABLE RNA-GUIDED ENDONUCLEASES AND METHODS OF USE THEREOF (GeoCas9)
• Cas12c/C2C3 Compositions and Methods of Use
• Endoribonucleases For Rna Detection And Analysis

Tech ID/UC Case

28913/2018-045-0

Related Cases

2018-045-0

USA