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Taurine Boosts Intracellular Delivery of Functional Molecules

Technology Benefits

· Covalent conjugation of taurine is abroadlyapplicable approach to boost the intracellulardelivery of bioactivemolecular and therapeuticagents· The taurine motif ensurestransportation and thesubsequent intracellular nanofibrils formationunderenzymatic catalysis can efficiently reducethe molecular diffusion outside ofcells, providing anew mechanism that eradicates drug resistance.· This method avoids the possibilityof immuneresponse and toxicity caused by CPPs· The natural and non-proteinogenicamino acid,taurine, is widely available, accessible, and itsmolecularmodification facile

Technology Application

· As an effective method to delivertherapeutic agents, genes, proteins, and siRNA through otherwise imperviouscellular membranes into targeted cells· A fluorophore may also be conjugated toallowfor intracellular imaging studies

Detailed Technology Description

Taurine modified D-peptide conjugates significantly enhances cellular uptake of therapeutic molecules for disease diagnosis and treatment.

Countries

United States

Application No.

62/121,237

Country/Region

USA

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