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CTP synthase 1 (CTPS1) inhibitors for treating neointima-related disorders
Detailed Technology Description
Thetechnology is a method of blockading CTPS1 as a target for therapeutics intreating neointima-related disorders. Specifically, the invention aims to be vascularsmooth muscle specific anti-proliferative drugs for the next-generation drugeluting stents. Vascular remodeling as a result of smooth muscle cell (SMC)proliferation and neointima formation is a major medical challenge incardiovascular intervention. However, antineointima drugs often indistinguishablyblock re-endothelialization, an essential step toward successful vascularrepair, because of their nonspecific effect on endothelial cells (ECs). Analternative treatment is then highly desirable.
Country/Region
USA
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