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Arysulfanyl Pyrazolone to Block SOD1 Aggregation for the Treatment of Amyotrophic Lateral Sclerosis
Technology Benefits
Proof-of-concept in ALS mouse models. Initial proof-of concept in other cell lines and additional animal modelsNorthwestern University’s unique strength in battling ALS lies in having dedicated researchers, including Teepu Siddique (Feinberg), who spearheaded the creation of a “research standard” model system for ALS.
Detailed Technology Description
Three series of New Chemical Entities (NCEs) that exhibited efficacy in an ALS animal model were identified and are potentially useful for the treatment of ALS and other motor neuron diseases. #Therapeutic #CNS #small molecule #ALS # Lou Gehrig's disease #motor neuron disease
Country/Region
USA
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