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Mithramycin analogues and their application against Ewing sarcoma - 2004
Technology Benefits
Aberrantregulation of FLI1 as well as other transcription factors (eg ERG) areimplicated in several cancers and often result in malignant transformations. Acharacteristic of Ewing Sarcoma involves a chromosomal translocation resultingin a chimeric EWS-FLI1 fusion protein. Mithramycin has been identified as apotent inhibitor of EWS-FLI1, but has also proved to be highly toxic tonon-sarcoma cells. To address this, Rohr and colleagues have created MTManalogues to improve the performance, selectivity, and efficacy of MTM.
Detailed Technology Description
None
Country/Region
USA
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