Pharmacogenomics of Intergenic SNPs and in Silico Modeling for Precision Therapy

Title: Pharmacogenics of Intergenic SNPs and in Silico Modeling for Precision Therapy Invention: A method for analyzing a single patient’s DNA and modeling how mutations and variations in intra-cell genomics will be expressed in the body. The information may be used to develop highly personalized therapies without the need for huge experimental data sets. Background: Personalized medicine is the next frontier in therapeutics. Unfortunately, highly specific therapies are virtually incompatible with traditional research methods, which focus on generalized efficacy in cohort-level studies. Because of this, inventors at the University of Arizona sought to create a method that personalized therapeutic profiles using data from only the individual patient. Without the need for cohort-level data, therapies can be more efficiently tailored to a patient's genome and, more importantly, the specific effects of the disease on their genome and vice versa.  Applications: Target critical pathways for drug therapiesDevelopment of personalized medicine based on personal genetic mutations/variationsResearch links between genetic variations and disease pathologies Advantages: Employs single-subject data analysis by only requiring information about the patientCapable of using as few as two disease-affected cellsConsiders intra-cellular genetic heterogeneity Accounts for cell-to-cell variations and how these variations affect gene expression in the body as a whole Licensing Manager:  Rakhi GibbonsRakhiG@tla.arizona.edu(520) 626-6695

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