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Automated Rapid Reaction Screening by DESI-MS

Summary

Researchers at Purdue University have developed systems and methods for conducting reactions and screening for reaction products. This method is based on desorption electrospray ionization (DESI) of the reaction mixture to produce microdroplets containing the reagents. Within the droplets, the reagents can react at accelerated rates. The droplets are directed towards a mass spectrometer (MS) and their contents are monitored online using MS. This method offers accelerated screened reactions, with analysis performed online and in concert with reaction, and the speed of DESI analysis allows for the analysis in a single experiment of a large numbers of different reactions mixtures.

Technology Benefits

RapidAutomaticUses existing equipment

Technology Application

Chemical analysisMicrofluidics

Detailed Technology Description

R. Graham CooksPurdue ChemistryAston Labs

Countries

United States

Application No.

None

Country/Region

USA

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