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A Way to Genetically Silence Calcium Signaling in Cells and Organisms and Derivates Thereof

Technology Benefits

Genetic silencing avoids off-target effects of small molecule inhibitorsGene-specific silencing opens opportunity to discover disease mechanism

Technology Application

Explore contributions of calcium signals to disease processesIdentify new therapeutic targets

Detailed Technology Description

Researchers at UCLA have modified the traditional Cre-loxP system to include an astrocyte-specific locus to specifically and extensively silence specific genes of interest pertaining to calcium regulation. In doing so, the mouse model allows for specific, regulated, and pas-astrocytic gene expression under very specific conditions. This platform can be expanded to other gene loci and cell types.

Others

Background

Current genetic silencing protocols have flaws in their selectivity and extensiveness. For example, a key necessity to studying astrocytes in vivo is the ability to manipulate them selectively without concomitantly impacting other cells. From this perspective, much attention has focused on genetic methods to selectively target astrocytes. Cell-type-specific expression of Cre recombinase (Cre) is frequently used to achieve gene expression and deletion by exploiting the Cre-loxP system. However, existing mouse lines expressing Cre under the control of astrocyte promoters are neither selective for astrocytes nor pan-astrocytic.

Related Materials

Tech ID/UC Case

28702/2016-99C-0

Related Cases

2016-99C-0

Country/Region

USA

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