AsiaIPEX is a one-stop-shop for players in the IP industry, facilitating IP trade and connection to the IP world. Whether you are a patent owner interested in selling your IP, or a manufacturer looking to buy technologies to upgrade your operation, you will find the portal a useful resource.

Back to search results

A Method for Inhibition of de novo Lipogenesis

Technology Application

This invention provides a method of treating nonalcoholic steatohepatits (NASH), nonalcoholic fatty liver disease (NAFLD), and/or de novo lipogenesis (DNL) in humans. This method may also be used to potentially treat hepatocellular carcinoma.

Detailed Technology Description

Researchers at UC San Diego have identified a biochemical pathway responsible for activation of SREBP1/2 in mice suffering from NASH and demonstrates that the same pathway is active in human NASH patients. The invention demonstrates that inhibition of a critical component of this pathway reverses all NASH related symptoms in mice and prevents fat accumulation in liver and enhances energy expenditure.

Others

State Of Development

A prototype model has identified a crucial component of the pathway responsible for stimulation of de novo lipogenesis during NAFLD and NASH and have demonstrated its inhibition using a non-proprietary inhibitor which blocks DNA, increases energy expenditure and reverses NASH symptoms in a mouse model.

Intellectual Property Info

A provisional patent has been submitted.

Tech ID/UC Case

27665/2017-157-0

Related Cases

2017-157-0

Country/Region

USA

For more information, please click Here