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Therapy for Restoration of Impaired Insulin Secretion

Detailed Technology Description

This invention describes the use of ebselen in the treatment for diabetes and hypoglycemia, which has been shown to improve glucose-stimulated insulin secretion (GSIS) in islets.

Others

Patent application No. US 2015/0297564
X. Wang, J-W Yun, and X. G. Lei. (2014). Glutathione peroxidase mimic ebselen improves glucose-stimulated insulinsecretion in murine islets. Antioxidants& Redox Signaling. Vol.20(2): 191-203. DOI:10.1089/ars.2013.5361
X.Wang, et al. (2011). Knockouts of SOD1 and GPX1 Exert Different Impactson Murine Islet Function and Pancreatic Integrity. Antioxidants & Redox Signaling. Vol.14(3):391-401. DOI: 10.1089/ars.2010.3302.

Country/Region

USA

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