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Targeting the DDB1-CUL4A Ubiquitin Ligase for Cancer Prevention and Intervention
Detailed Technology Description
This invention teaches an approach and provides examples of agents that can prolong the activities of the NER (Nucleotide excision repair) enzyme, and therefore, enhance the cellular ability to repair DNA damages caused by environmental carcinogens and oxidation stress. This invention may find a wide range of applications in skin care and in conditions that benefit from the enhancement of DNA repair including cancer prevention and treatment. A method for screening for such agents is also taught.
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Country/Region
USA
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