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Crown-Like Structures as Biomarkers for Cancer Risk and Cancer Prognosis

Detailed Technology Description

This invention identifies a crown-like structure (CLS) in adipose tissue and demonstrates that CLS’s can be used as biomarkers for risk or poor prognosis in breast cancer and other malignancies in overweight or obese individuals.

Others

Obesity is Associated with Inflammation and Elevated Aromatase Expression in the Mouse Mammary Gland, Cancer Prev Res, 2011; 4: 329-346
Inflammation and Increased Aromatase Expression Occur in the Breast Tissue of Obese Women with Breast Cancer, Cancer Prev Res, 2011; 4: 1021-1029
Increased levels of COX-2 and prostaglandin E2 contribute to elevated aromatase expression in inflamed breast tissue of obese women. Cancer Discov. 2012; 2: 356-365

Country/Region

USA

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