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Probiotics Expressing GLP-1 as an Aid to prevent or Treat Diabetes

Detailed Technology Description

The technology provides recombinant cells and methodsusing commensal bacteria for the prevention and treatment of diabetes ormetabolic syndromes.

Others

Patents issued in the U.S. 8,771,668 (D-4291) and 9,265,842 (D-5208)
Patents issued in the Europe EP2274416 (D-4291) and EP2627770(D-5208)
Duan, F., Curtis, K. L. and March, J. C. (2008).Secreting insulinotropic proteins from commensal bacteria: rewiring the gut totreat diabetes. Applied and Environmental Microbiology, 74: 7437-7438
Duan,F., Liu, J. H. and March, J. C. (2015). Engineered commensal bacteria reprogram intestinal cells intoglucose-responsive insulin-secreting cells for the treatment of diabetes. Diabetes, 64: 1794-1803.

Country/Region

USA

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