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Protein Knockout Platform

Detailed Technology Description

Methods to eradicate proteins at mRNA and protein levelsKitscomprising engineered SCF ubiquitin ligase and corresponding siRNA

Others

Published US Patent Application US20130011920
Zhou P, et al Harnessing the ubiquitination machinery to target the degradation of specific cellular proteins. Mol Cell. 2000 Sep;6(3):751-6 (Pubmed 11030355)
Zhang J, Zheng N, Zhou P. Exploring the functional complexity of cellular proteins by protein knockout. PNAS. 2003 Nov 25;100(24):14127-32. (Pubmed 14593203)
Cong F e al. A protein knockdown strategy to study the function of beta-catenin in tumorigenesis. BMC Mol Biol. 2003 Sep 29;4:10. (Pubmed 14516475)
Cohen JC et al Transient in utero knockout (TIUKO) of C-MYC affects late lung and intestinal development in the mouse. BMC Dev Biol. 2004 Apr 16;4:4. (Pubmed 15090077)
Zhou P. Targeted protein degradation. Curr Opin Chem Biol. 2005 (Pubmed 15701453)

Country/Region

USA

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