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Breast Lesion Characterization Using Contrast Mammography

Technology Benefits

(1) Less expensive and less time-consuming than other methods; (2) Currently, contrast-enhanced MRI is the most sensitive employed tool, but is prohibitively expensive or unavailable to many patients; (3) Better at discerning benign and malignant lesions, thus limiting the number of biopsies and false-positive diagnoses; (4) Traditional contrast mammography does not have the sensitivity to differentiate benign and malignant lesions; and (5) This technique analyzes tissue vascularity and correlates lesion thickness more accurately using novel calculations of contrast agent signals.

Technology Application

(1) Screening and diagnosis of breast cancer; and (2) Monitoring lesions throughout treatment.

Detailed Technology Description

Contrast mammography images the breast after an injection of a contrast agent, which concentrates in the area of tumors (due to the high vascularity of these types of lesions). This traditional method, however, has limited accuracy, as detection of the contrast agent signals may be obscured by the adipose (fatty) and glandular tissues of the breast. UCI researchers have modeled the breast as a two-compartment structure, and applied a new calculation approach that subtracts extraneous tissue “noise” from the contrast agent signal. This technique can accurately correlate the measured signal to the thickness and severity of the lesion, unlike any other current contrast mammography methodology.

Others

Tech ID/UC Case

27553/2016-757-0

Related Cases

2016-757-0

Country/Region

USA

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