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Catalytic Coupling Reactions Using Frameworks with Open-Metal-Sites
Technology Benefits
• Copper-based catalyst• Catalysts are easily produced• High chemical and temperature stability
Technology Application
• Coupling-reaction catalyst• Drug Precursor Synthesis
Detailed Technology Description
Dr. Omar Yaghi and colleagues at UCLA have developed a copper (Cu)-based metal organic framework and metal organic polyhedra that can be used as a catalyst in a homo-coupling synthesis reaction to generate biaryls. The catalyst was demonstrated to have up to 95% conversion and 90% selectivity as well as having high chemical stability.
Application No.
9045387
Others
State Of Development
A series of Suzuki homo-coupling and Chan-Lam coupling reactions have been successfully performed using various MOFs and MOPs.
Background
Coupling reactions are used in organic chemistry to join two hydrocarbons. Because of the importance of hydrocarbons, coupling reactions are widely utilized in the pharmaceutical industry as well as in industrial chemistry. In coupling reactions, a metal catalyst such as Palladium (Pd) is traditionally used. Other traditionally used catalyst include Cr (II), Pb (II), Mn (IV), Ti (II), and Ni (II). Problems using these metal catalysts include poor yields, poor selectivity, environmentally-unfriendly, and restricted operating conditions. A better catalytic system for coupling reactions will be highly beneficial to both the pharmaceutical and industrial industry by improving material economy and minimizing environmental toxicity.
