Monoclonal Antibodies Against GPIHBP1
- Technology Application
- Western, IHC, ICC
- Detailed Technology Description
- Researchers at UCLA have developed monoclonal antibodies that recognize mouse and human glycosylphosphatidylinositol-anchored high density lipoprotein binding protein 1 (GPIHBP1).Rat monoclonal antibody, 11A12, against mouse GPIHBP1Mouse monoclonal antibody against human GPIHBP1
- Others
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Background
Dietary fats are packaged by the intestines into triglyceride-rich lipoproteins called chylomicrons. The triglycerides in chylomicrons are hydrolyzed by lipoprotein lipase (LPL) along the luminal surface of capillaries, mainly in heart, skeletal muscle, and adipose tissue. GPIHBP1 is a capillary endothelial cell protein that provides a platform for LPL-mediated processing of chylomicrons (Beigneux et al., 2007 [PubMed 17403372]). Related Materials
Highly Conserved Cysteines within the Ly6 Domain of GPIHBP1 Are Crucial for the Binding of Lipoprotein Lipase. J Biol Chem. (2009)
GPIHBP1 is responsible for the entry of lipoprotein lipase into capillaries. Cell Metab. (2010)Additional Technologies by these Inventors
Tech ID/UC Case
23751/2014-255-0
Related Cases
2014-255-0
- *Abstract
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None
- *Principal Investigator
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Name: Loren Fong
Department:
Name: Stephen Young
Department:
- Country/Region
- USA
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