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Novel Micro-Calorimeter Device for Drug Discovery and Biochemical Analysis

Technology Benefits

Highly sensitive Can accept reaction values down to 1/1000th of the state of the art Operates in both liquid and gaseous environments Compatible with automatic high throughput handling systems Compatible with biotech industrial processes Manufacturable in arrays

Technology Application

Calorimeter Drug discovery Biochemical analysis

Detailed Technology Description

Researchers at UCLA have developed a micro-scale calorimeter using piezoresistive and/or piezoelectric materials as a sensor element to reduce necessary sample activity by 1000-fold.

Supplementary Information

Patent Number: US8501092B2
Application Number: US2003589430A
Inventor: Gimzewski, James K.
Priority Date: 15 Apr 2004
Priority Number: US8501092B2
Application Date: 30 Jan 2007
Publication Date: 6 Aug 2013
IPC Current: G01N003300 | G01K000116 | G01K001700
US Class: 422051 | 4220681 | 42208201 | 42208202
Assignee Applicant: The Regents of the University of California
Title: Calorimeter and methods of use thereof
Usefulness: Calorimeter and methods of use thereof
Summary: For measuring heat absorbed or generated from chemical, biochemical, physical, light-induced, and biological processes.
Novelty: Calorimeter, for measuring heat absorbed or generated from chemical, biochemical, physical, light-induced, and biological processes, includes U-shaped reaction vessel mounted onto support block, and temperature sensor

Industry

Electronics

Sub Group

Circuit Design

Application No.

8501092

Others

Background

Microcalorimeters are devices that measure very small quantities of heat in the fields of chemistry, biochemistry, cell biology, and pharmacology to measure thermodynamic properties of biological macromolecules, such as proteins. Two commonly used types of microcalorimeters are the differential scanning calorimeter (DSC) and the isothermal titration calorimeter (ITC). This invention enables high sensitivity qualitative calorimetric analysis for thermodynamic and kinetic determination of reaction enthalpy reaction kinetics, etc. The key feature of the device is that it operates in liquids and gaseous environments in comparison ITC and DTC. This invention requires reaction values up to x1,000 less and suited to proteomic or small molecule studies for drug discovery and biochemical analysis. The technique is compatible with high throughput, automatic sample handling systems and also compatible with biotech industrial processes. In addition, the calorimeter can also be used as a photothermal spectrometer or IR-spectrometer based on the thermal signal, generated by IR, visible, or UV absorption.

Additional Technologies by these Inventors

Tech ID/UC Case

22323/2004-395-0

Related Cases

2004-395-0

Country/Region

USA

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