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Male Mice Lacking Sry on the Y Chromosome with a Function Autosomal Sry Transgene

Technology Benefits

New candidate pathwaysBetter understanding on the mechanism of action for antidepressantsSimple and convenient assay that may be used in high throughput format

Technology Application

This mouse strain allows investigation of the separate actions, and interactions, of different types of sex-specific forces (hormonal and chromosomal) that cause sex differences.

Detailed Technology Description

UCLA researchers have developed mice in which the Sry gene is deleted from the Y chromosome and inserted onto an autosome as a transgene, effectively transferring testis determination from the Y chromosome to an autosome. When male mice carrying the Sry transgene are mated to wild-type females, they produce four "core" genotypes that can be used as a model to investigate relationships between sex chromosome complement (XX or XY) and gonadal type that influences phenotypic characteristics.

Others

Related Materials

Chen X, et al. Sex difference in neural tube defects in p53-null mice is caused by differences in the complement of X not Y genes. Dev Neurobiol. 2008 Feb 1;68(2):265-73.
Additional Information on Mouse Strain #010905 from The Jackson Laboratory

Tech ID/UC Case

21499/2010-496-0

Related Cases

2010-496-0

Country/Region

USA

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